Myc^tm1Jlc
Targeted Allele Detail

Summary

• Symbol: Myc^tm1Jlc
• Name: myelocytomatosis oncogene; targeted mutation 1, John L Cleveland
• MGI ID: MGI:2388702
• Synonyms: c-myc^-
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1Jlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79427
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a gpt selection cassette. Expression analysis of homozygous mutant ES cells indicated an absence of protein product. (J:4556)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:79427 Baudino TA, et al., c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002 Oct 1;16(19):2530-43
• All: 6 reference(s)