Gpx1^tm1Kola
Targeted Allele Detail

Summary

• Symbol: Gpx1^tm1Kola
• Name: glutathione peroxidase 1; targeted mutation 1, Ismail Kola
• MGI ID: MGI:2388705
• Synonyms: Gpx1-
• Gene: Gpx1 Location: Chr9:108216279-108217541 bp, + strand Genetic Position: Chr9, 59.24 cM, cytoband F1
• Alliance: Gpx1^tm1Kola page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49644
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 via homologous recombination. Northern blot analysis failed to detect gene expression in any of the tissues examined from homozygous mutant animals (brain, heart, kidney, liver, and lung). (J:49644)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gpx1 Mutation: 21 strains or lines available

References

• Original: J:49644 de Haan JB, et al., Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem. 1998 Aug 28;273(35):22528-36
• All: 24 reference(s)