Star^tm1Klp
Targeted Allele Detail

Summary

• Symbol: Star^tm1Klp
• Name: steroidogenic acute regulatory protein; targeted mutation 1, Keith L Parker
• MGI ID: MGI:2388706
• Gene: Star Location: Chr8:26298502-26306010 bp, + strand Genetic Position: Chr8, 14.17 cM
• Alliance: Star^tm1Klp page

Histology of the adrenal gland from wild type and Star^tm1Klp/Star^tm1Klp mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43589
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Normal protein was undetected by Western blot analysis of adrenal extracts from homozygous mutant mice. (J:43589)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Star Mutation: 15 strains or lines available

References

• Original: J:43589 Caron KM, et al., Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11540-5
• All: 9 reference(s)