Tg(Lck-Map3k8)3456Ngc
Transgene Detail

Summary

• Symbol: Tg(Lck-Map3k8)3456Ngc
• Name: transgene insertion 3456, Neal G Copeland
• MGI ID: MGI:2388710
• Synonyms: Tpl-2tr
• Transgene: Tg(Lck-Map3k8)3456Ngc Location: unknown
• Alliance: Tg(Lck-Map3k8)3456Ngc page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Map3k8)3456Ngc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Map3k8 (MGI:1346878)

• Mutation details: A modified Map3k8 cDNA in which viral LTR sequence replaced exon 8 was adjoined to a lck proximal promoter, active in thymocytes. The transgene encodes a truncated protein which lacks the 23 carboxy terminal residues, resembling the truncated protein which is produced after integration of the Moloney murine leukemia virus (MoMLV) at the Map3k8 locus. Expression analysis confirmed the expression of a truncated protein. (J:39450)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:39450 Ceci JD, et al., Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev. 1997 Mar 15;11(6):688-700
• All: 1 reference(s)