Abr^tm1Jhg
Targeted Allele Detail

Summary

• Symbol: Abr^tm1Jhg
• Name: active BCR-related gene; targeted mutation 1, John H Groffen
• MGI ID: MGI:2388713
• Synonyms: Abr -/1
• Gene: Abr Location: Chr11:76307560-76468515 bp, - strand Genetic Position: Chr11, 45.92 cM
• Alliance: Abr^tm1Jhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72425
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 3. Immunoblotting confirmed the absence of the gene product in homozygous mice. (J:72425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abr Mutation: 66 strains or lines available

References

• Original: J:72425 Kaartinen V, et al., Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development. 2001 Nov;128(21):4217-27
• All: 8 reference(s)