Map3k8^tm1Pnt
Targeted Allele Detail

Summary

• Symbol: Map3k8^tm1Pnt
• Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Phillip Tsichlis
• MGI ID: MGI:2388714
• Synonyms: Map3k8^tm1Ceci, Tpl2 -
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^tm1Pnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66503
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from within exon 3 to within exon 5 was replaced by a neomycin selection cassette. The deleted region encoded a portion of the catalytic domain including ATP binding site and the activation loop. Transcript was detected by Northern blot analysis of homozygous mutant splenocytes. (J:66503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:66503 Dumitru CD, et al., TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell. 2000 Dec 22;103(7):1071-83
• All: 52 reference(s)