Mycn^tm1Psk
Targeted Allele Detail

Summary

• Symbol: Mycn^tm1Psk
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1, Paul S Knoepfler
• MGI ID: MGI:2388717
• Synonyms: Mycn^loxp, Mycn^tm1Rne, Nmyc^Fl, N-myc^FL
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm1Psk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Sequence encompassing exons 2 and 3 was flanked by a single loxP site upstream and a floxed neo cassette downstream. RT-PCR analysis revealed a 25% to 30% reduction in the amount of transcript in homozygous mutant mice. (J:79489)

Expression

In Mice Carrying this Mutation:	104056 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 2 lines available
• Carrying any Mycn Mutation: 25 strains or lines available

References

• Original: J:79489 Knoepfler PS, et al., N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002 Oct 15;16(20):2699-712
• All: 29 reference(s)