Mycn^tm1.1Psk
Targeted Allele Detail

Summary

• Symbol: Mycn^tm1.1Psk
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1.1, Paul S Knoepfler
• MGI ID: MGI:2388718
• Synonyms: Mycn^tm1.1Rne, N-myc^delta
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm1.1Psk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Transient expression of cre recombinase in ES cells excised the floxed fragment containing exons 2 and 3 and a neo cassette from Nmyc1^tm1Psk. (J:79489)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycn Mutation: 25 strains or lines available

References

• Original: J:79489 Knoepfler PS, et al., N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002 Oct 15;16(20):2699-712
• All: 4 reference(s)