Foxd3^tm2Lby
Targeted Allele Detail

Summary

• Symbol: Foxd3^tm2Lby
• Name: forkhead box D3; targeted mutation 2, Patricia A Labosky
• MGI ID: MGI:2388721
• Synonyms: Foxd3^-, Foxd3^Gfp
• Gene: Foxd3 Location: Chr4:99544536-99546859 bp, + strand Genetic Position: Chr4, 45.71 cM
• Alliance: Foxd3^tm2Lby page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79491
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous gene was replaced with a cassette containing GFP. A fusion transcript consisting of the endogenous 5' untranslated region and GFP was produced. GFP fluorescence was detected in the neural crest after 8.5 dpc. (J:79491)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxd3 Mutation: 10 strains or lines available

References

• Original: J:79491 Hanna LA, et al., Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002 Oct 15;16(20):2650-61
• All: 11 reference(s)