Afp^tm2Ibmm
Targeted Allele Detail

Summary

• Symbol: Afp^tm2Ibmm
• Name: alpha fetoprotein; targeted mutation 2, Claude Szpirer
• MGI ID: MGI:2388723
• Gene: Afp Location: Chr5:90638596-90656766 bp, + strand Genetic Position: Chr5, 44.77 cM
• Alliance: Afp^tm2Ibmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79500
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 and all of exon 3 were replaced by a cassette containing lacZ and floxed neo. Beta-galactosidase expression was putatively driven by both promoters, which were left intact by the insertion. (J:79500)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Afp Mutation: 32 strains or lines available

References

• Original: J:79500 Gabant P, et al., Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70
• All: 4 reference(s)