About   Help   FAQ
Afptm2Ibmm
Targeted Allele Detail
Summary
Symbol: Afptm2Ibmm
Name: alpha fetoprotein; targeted mutation 2, Claude Szpirer
MGI ID: MGI:2388723
Gene: Afp  Location: Chr5:90638596-90656766 bp, + strand  Genetic Position: Chr5, 44.77 cM
Alliance: Afptm2Ibmm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79500
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 2 and all of exon 3 were replaced by a cassette containing lacZ and floxed neo. Beta-galactosidase expression was putatively driven by both promoters, which were left intact by the insertion. (J:79500)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Afp Mutation:  32 strains or lines available
References
Original:  J:79500 Gabant P, et al., Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory