Tnfsf4^tm1Sug
Targeted Allele Detail

Summary

• Symbol: Tnfsf4^tm1Sug
• Name: tumor necrosis factor (ligand) superfamily, member 4; targeted mutation 1, Kazuo Sugamura
• MGI ID: MGI:2388724
• Synonyms: OX40-KO, OX40L-
• Gene: Tnfsf4 Location: Chr1:161223009-161245777 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Tnfsf4^tm1Sug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59412
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by FACS analysis of activated B cells obtained from homozygous mutant mice. (J:59412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf4 Mutation: 33 strains or lines available

References

• Original: J:59412 Murata K, et al., Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med. 2000 Jan 17;191(2):365-74
• All: 15 reference(s)