Il12a^tm1Cab
Targeted Allele Detail

Summary

• Symbol: Il12a^tm1Cab
• Name: interleukin 12a; targeted mutation 1, Christine A Biron
• MGI ID: MGI:2388729
• Synonyms: IL-12P35^-, p35^-
• Gene: Il12a Location: Chr3:68597977-68605880 bp, + strand Genetic Position: Chr3, 31.92 cM
• Alliance: Il12a^tm1Cab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54482
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 4 were replaced with a neomycin selection cassette. Interleukin 12 heterodimers were undetected after LPS stimulation or MCMV infection. (J:54482)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il12a Mutation: 35 strains or lines available

References

• Original: J:54482 Cousens LP, et al., Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J Exp Med. 1999 Apr 19;189(8):1315-28
• All: 6 reference(s)