Stat4^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Stat4^tm1Jni
• Name: signal transducer and activator of transcription 4; targeted mutation 1, James N Ihle
• MGI ID: MGI:2388732
• Synonyms: stat4^-
• Gene: Stat4 Location: Chr1:52026307-52146348 bp, + strand Genetic Position: Chr1, 26.67 cM
• Alliance: Stat4^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34060
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a hygromycin selection cassette. Protein was undetected by immunoprecipitation followed by Western blot analysis of spleen and testes extracts. (J:34060)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat4 Mutation: 64 strains or lines available

References

• Original: J:34060 Thierfelder WE, et al., Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996 Jul 11;382(6587):171-4
• All: 20 reference(s)