Art2a^tm1Fkn
Targeted Allele Detail

Summary

• Symbol: Art2a^tm1Fkn
• Name: ADP-ribosyltransferase 2a; targeted mutation 1, Friedrich Koch-Noltet
• MGI ID: MGI:2388822
• Synonyms: ART2.1-
• Gene: Art2a Location: Chr7:101201660-101210072 bp, - strand Genetic Position: Chr7, 54.6 cM
• Alliance: Art2a^tm1Fkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79607
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The coding region was disrupted by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of T cells isolated from lymph nodes. (J:79607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Art2a Mutation: 9 strains or lines available

Notes

Successfully targeted ES cells were subsequently targeted with the construct for the Art2b allele.

References

• Original: J:79607 Ohlrogge W, et al., Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Mol Cell Biol. 2002 Nov;22(21):7535-42
• All: 10 reference(s)