Bomd2^DBA/2
QTL Variant Detail

Summary

• QTL variant: Bomd2^DBA/2
• Name: bone mineral density 2; DBA/2
• MGI ID: MGI:2388880
• QTL: Bomd2 Location: Chr14:10227723-10916220 bp Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50828

24 BXD RI (recombinant inbred) strains were analyzed for loci associated with bone mineral density (BMD) and body weight in 12-week-old female animals. Progenitor strain C57BL/6 exhibits greater bone mass than progenitor strain DBA/2 at 84 days of age, but body weight is very similar between the 2 strains. After screening over 1500 informative markers on a BXD mapping panel 10 provisional QTLs associated with BMD mapped to 9 different chromosomes and await confirmation. Two of the most significant BMD QTLs (P = 0.0007), Bomd1, mapped to mouse Chromosome 7 at 44 cM (in linkage with D7Mit234), and Bomd2, mapped to mouse chromosome 14 at 2 cM (in linkage with Ptprg). Possible candidate genes for Bomd1 are the insulin-like growth factor I receptor (Igf1r), parathyroid hormone (Pth), and calcitonin (Calca, previously Ct). A possible candidate gene for Bomd2 is bone morphogenetic protein 4 (Bmp4).

References

• Original: J:50828 Klein RF, et al., Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res. 1998 Nov;13(11):1648-56
• All: 1 reference(s)