Elf4^tm1Nim
Targeted Allele Detail

Summary

• Symbol: Elf4^tm1Nim
• Name: E74 like ETS transcription factor 4; targeted mutation 1, Stephen D Nimer
• MGI ID: MGI:2388892
• Synonyms: MEF-
• Gene: Elf4 Location: ChrX:47499926-47552009 bp, - strand Genetic Position: ChrX, 25.67 cM, cytoband A3.2
• Alliance: Elf4^tm1Nim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79568
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region including the ETS domain was replaced by a neomycin selection cassette inserted by homologous recombination. RT-PCR analysis of bone marrow cells isolated from homozygous mutant (female) mice showed a lack of transcript. The absence of protein was demonstrated by Western blot analysis of thymic lysates. (J:79568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elf4 Mutation: 19 strains or lines available

References

• Original: J:79568 Lacorazza HD, et al., The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer and NK-T Cells. Immunity. 2002 Oct;17(4):437
• All: 17 reference(s)