Canx^tm1Den
Targeted Allele Detail

Summary

• Symbol: Canx^tm1Den
• Name: calnexin; targeted mutation 1, Angela Denzel
• MGI ID: MGI:2388893
• Synonyms: cnx^-
• Gene: Canx Location: Chr11:50184788-50216500 bp, - strand Genetic Position: Chr11, 30.46 cM
• Alliance: Canx^tm1Den page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79604
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment encompassing 137 bp of exon 4, intron 4, and all of exon 5 was replaced with a floxed selection cassette. Protein was undetected in homozygous mutant mice by Western blot analysis using amino- and carboxyl-terminal antibodies. (J:79604)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Canx Mutation: 55 strains or lines available

References

• Original: J:79604 Denzel A, et al., Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol. 2002 Nov;22(21):7398-404
• All: 2 reference(s)