Nfatc4^tm1Jmk
Targeted Allele Detail

Summary

• Symbol: Nfatc4^tm1Jmk
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4; targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:2388915
• Gene: Nfatc4 Location: Chr14:56062252-56071400 bp, + strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Nfatc4^tm1Jmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79608
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the Rel homology domain. Neither transcript nor protein was detected in cardiac tissue obtained from homozygous mutant mice. (J:79608)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfatc4 Mutation: 38 strains or lines available

References

• Original: J:79608 Wilkins BJ, et al., Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth. Mol Cell Biol. 2002 Nov;22(21):7603-13
• All: 5 reference(s)