Bcan^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Bcan^tm1Ref
• Name: brevican; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:2388924
• Synonyms: BC-
• Gene: Bcan Location: Chr3:87894838-87907537 bp, - strand Genetic Position: Chr3, 38.78 cM
• Alliance: Bcan^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79605
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous gene was replaced with a promoterless lacZ and a neomycin selection cassette. The absence of transcript and protein was determined via Northern and Western blot analysis of homozygous mutant mice. (J:79605)

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcan Mutation: 47 strains or lines available

References

• Original: J:79605 Brakebusch C, et al., Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol. 2002 Nov;22(21):7417-27
• All: 11 reference(s)