Cox17^tm1Kako
Targeted Allele Detail

Summary

• Symbol: Cox17^tm1Kako
• Name: cytochrome c oxidase assembly protein 17, copper chaperone; targeted mutation 1, Koichiro Kako
• MGI ID: MGI:2388937
• Synonyms: COX17(-)
• Gene: Cox17 Location: Chr16:38167332-38173125 bp, + strand Genetic Position: Chr16, 26.77 cM
• Alliance: Cox17^tm1Kako page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79609
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exons 1 and 2, as well as the intervening intron, were replaced with a construct containing GFP followed by neo. GFP was inserted immediately downstream of the endogenous start codon. Northern blot analysis of heterozygous mutant mice showed transcript levels to be reduced by approximately 50% in brain, heart, kidney, and skeletal muscle samples. (J:79609)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cox17 Mutation: 8 strains or lines available

References

• Original: J:79609 Takahashi Y, et al., Mammalian copper chaperone cox17p has an essential role in activation of cytochrome C oxidase and embryonic development. Mol Cell Biol. 2002 Nov;22(21):7614-21
• All: 1 reference(s)