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Csf3rtm4(Epor)Link
Targeted Allele Detail
Summary
Symbol: Csf3rtm4(Epor)Link
Name: colony stimulating factor 3 receptor; targeted mutation 4, Daniel C Link
MGI ID: MGI:2388978
Synonyms: GE, G:EpoR
Gene: Csf3r  Location: Chr4:125918343-125938233 bp, + strand  Genetic Position: Chr4, 59.77 cM
Alliance: Csf3rtm4(Epor)Link page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79825
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 16 and 17 of the endogenous gene, which encode the cytoplasmic domain, were replaced by an Epor cDNA fragment. The resultant allele encodes a chimeric receptor with the endogenous extracytoplasmic (ligand binding) and transmembrane regions adjoined to the Epor cytoplasmic (signaling) region. Flow cytometric and ligand binding assays indicated that the chimeric receptor had normal binding affinity and was expressed on the surface of homozygous mutant neutrophils at a level approximately 80% of normal expression. (J:79825)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf3r Mutation:  42 strains or lines available
References
Original:  J:79825 Semerad CL, et al., A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity. 1999 Aug;11(2):153-61
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory