Mllt3^tm1.1Thr
Targeted Allele Detail

Summary

• Symbol: Mllt3^tm1.1Thr
• Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3; targeted mutation 1.1, Terence H Rabbitts
• MGI ID: MGI:2388982
• Synonyms: Af9^-, Af9NO
• Gene: Mllt3 Location: Chr4:87688162-87951601 bp, - strand Genetic Position: Chr4, 41.06 cM
• Alliance: Mllt3^tm1.1Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79367
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The second coding exon of the endogenous gene was disrupted by homologous recombination of a construct containing IRES-lacZ and a floxed neo gene and subsequent excision of the selection cassette. A single loxP site was left downstream of the lacZ reporter, which was expressed via the endogenous promoter. RT-PCR analysis of homozygous mutant mice showed a lack of normal transcript. (J:79367)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mllt3 Mutation: 31 strains or lines available

References

• Original: J:79367 Collins EC, et al., Mouse Af9 Is a Controller of Embryo Patterning, Like Mll, Whose Human Homologue Fuses with AF9 after Chromosomal Translocation in Leukemia. Mol Cell Biol. 2002 Oct;22(20):7313-24
• All: 2 reference(s)