Cdh1^tm2Kem
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm2Kem
• Name: cadherin 1; targeted mutation 2, Rolf Kemler
• MGI ID: MGI:2389020
• Synonyms: Ecad^fl, E-cadherin^flox, E-cadherin^floxed, E-cad^lox
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm2Kem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77170
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Single loxP sites flanked a region encompassing exons 6 through 10 followed by a floxed selection cassette was excised via in vitro cre mediated recombination. (J:77170)

Disease models

Expression

In Mice Carrying this Mutation:	12 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdh1^tm2Kem

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 173 strains or lines available

References

• Original: J:77170 Boussadia O, et al., E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002 Jul;115(1-2):53-62
• All: 76 reference(s)