Cdh1^tm2.1Kem
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm2.1Kem
• Name: cadherin 1; targeted mutation 2.1, Rolf Kemler
• MGI ID: MGI:2389021
• Synonyms: E-cadherin^flox-del
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm2.1Kem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77170
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encompassing exons 6 through 10 was deleted from Cdh1^tm2Kem via in vivo cre mediated recombination of flanking loxP sites. (J:77170)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 173 strains or lines available

References

• Original: J:77170 Boussadia O, et al., E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002 Jul;115(1-2):53-62
• All: 3 reference(s)