Tg(Myh6-ADRBK1)12Wjk
Transgene Detail

Summary

• Symbol: Tg(Myh6-ADRBK1)12Wjk
• Name: transgene insertion 12, Walter Koch
• MGI ID: MGI:2389028
• Synonyms: BetaARK1 transgene, Tg(BARK12)12Wjk, TGBetaK12, TgGRK2
• Transgene: Tg(Myh6-ADRBK1)12Wjk Location: unknown
• Alliance: Tg(Myh6-ADRBK1)12Wjk page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ADRBK1)12Wjk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pig, domestic	ADRBK1 (100513842)

• Tg(Myh6-ADRBK1)12Wjk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The entire bovine adrenergic receptor kinase, beta 1 (ADRBK1) coding region was ligated to a 5.5 kb fragment of the murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Overexpression of the transgenic protein was detected by Western blot analysis of heart extracts. Biochemical assays showed that kinase activity was approximately 3 times greater in heart extracts from transgenic mice than from wild-type mice. The Myh6 promoter drives expression in myocardial tissue. (J:37034)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:37034 Koch WJ, et al., Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995 Jun 2;268(5215):1350-3
• All: 7 reference(s)