Tg(Myh6-ADRBK1)27Wjk
Transgene Detail

Summary

• Symbol: Tg(Myh6-ADRBK1)27Wjk
• Name: transgene insertion 27, Walter Koch
• MGI ID: MGI:2389030
• Synonyms: BetaARKct, TG betaARKct, Tg(minBARKct)27Wjk, TGMini27
• Transgene: Tg(Myh6-ADRBK1)27Wjk Location: unknown
• Alliance: Tg(Myh6-ADRBK1)27Wjk page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ADRBK1)27Wjk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GRK2 (156)

  Grk2	(MGI:87940)

• Tg(Myh6-ADRBK1)27Wjk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: Sequence encoding the carboxyl terminus of the bovine adrenergic receptor kinase, beta 1 (ADRBK1) (residues 495 through 689) was ligated to a 5.5 kb fragment of the murine adult myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. The resultant 194 residue carboxyl terminal peptide was detected by Western blot analysis and inhibits endogenous beta-adrenergic receptor kinase-1 by blocking beta-adrenergic receptor desensitization. The Myh6 promoter drives expression in myocardial tissue. (J:37034)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:37034 Koch WJ, et al., Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995 Jun 2;268(5215):1350-3
• All: 15 reference(s)