Dpep1^tm1Mwl
Targeted Allele Detail

Summary

• Symbol: Dpep1^tm1Mwl
• Name: dipeptidase 1; targeted mutation 1, Michael W Lieberman
• MGI ID: MGI:2389068
• Synonyms: MBD^-, MBD^m1
• Gene: Dpep1 Location: Chr8:123913069-123928551 bp, + strand Genetic Position: Chr8, 72.08 cM
• Alliance: Dpep1^tm1Mwl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47610
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 and flanking sequences with a PGK-Hprt cassette via homologous recombination. The gene targeting event results in deletion of a splice acceptor site necessary for processing different protein isoforms, a 16 amino acid signal sequence, and 18 amino acids of the mature protein. Northern blot analysis of various tissues from homozygous mutant animals using a 620 bp cDNA probe did not detect gene expression. (J:47610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpep1 Mutation: 25 strains or lines available

References

• Original: J:47610 Habib GM, et al., Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4859-63
• All: 2 reference(s)