Fembrs4^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Fembrs4^MRL/MpJ
• Name: femur breaking strength 4; MRL/MpJ
• MGI ID: MGI:2389081
• QTL: Fembrs4 Location: Chr17:32061652-32061760 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 17.25 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased bone strength compared to SJL/J. (J:76508)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76508

119 polymorphic markers were screened in 633 (MRL/MpJ x SJL/J)F2 female animals to detect loci associated with femur bone mineral density. 7-week old female animals were used for the study. Fembrs4 was identified on mouse Chromosome 17 with LOD=6 at D17Mit175. Fembrs4 also shows significant linkage to femur breaking strength (LOD=8.3) and other traits, such as body weight and femur length, suggesting pleiotropic effects. MRL/MpJ-derived alleles confer increased bone strength with recessive inheritance atFembrs4. A possible candidate gene for Fembrs4 is Map3k4.

References

• Original: J:76508 Li X, et al., Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJxSJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy. Genomics. 2002 May;79(5):734-40
• All: 2 reference(s)