Fembrs6^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Fembrs6^MRL/MpJ
• Name: femur breaking strength 6; MRL/MpJ
• MGI ID: MGI:2389087
• QTL: Fembrs6 Location: Chr9:76024387-76024534 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 42.48 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased bone strength compared to SJL/J. (J:76508)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Fembrs6 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76508

119 polymorphic markers were screened in 633 (MRL/MpJ x SJL/J)F2 female animals to detect loci associated with femur bone mineral density. 7-week old female animals were used for the study. Fembrs6 was identified on mouse Chromosome 9 with LOD=3.6 at D9Mit270.

References

• Original: J:76508 Li X, et al., Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJxSJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy. Genomics. 2002 May;79(5):734-40
• All: 1 reference(s)