Tg(KRT5-Ccnd3)2203Mlrp
Transgene Detail
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Symbol: |
Tg(KRT5-Ccnd3)2203Mlrp |
Name: |
transgene insertion 2203, Marcelo L Rodriguez-Puebla |
MGI ID: |
MGI:2389104 |
Transgene: |
Tg(KRT5-Ccnd3)2203Mlrp Location: unknown
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Alliance: |
Tg(KRT5-Ccnd3)2203Mlrp page
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Strain of Origin: |
C57BL/6 x SJL
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(KRT5-Ccnd3)2203Mlrp expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Ccnd3 (MGI:88315) |
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Tg(KRT5-Ccnd3)2203Mlrp expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
cattle |
KRT5 (281268) |
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Mutation details: Murine Ccnd3 cDNA sequence preceded by a beta-globin intron was ligated to 5.2 kb of bovine KRT5 regulatory sequence. The KRT5 promoter directed expression in basal cells of squamous stratified epithelia. Expression of the transgenic protein was detected by Western blot analysis of epidermal tissue. Quantification of the Western blot results indicated a nearly 5.5-fold increase relative to wild-type samples.
(J:64388)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:64388 Rodriguez-Puebla ML, et al., Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia. Am J Pathol. 2000 Sep;157(3):1039-50 |
All: |
4 reference(s) |
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