Hoxd11^{tm2.1(Hoxd11)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxd11^{tm2.1(Hoxd11)Mrc}
• Name: homeobox D11; targeted mutation 2.1, Mario R Capecchi
• MGI ID: MGI:2389127
• Synonyms: d11^Dp
• Gene: Hoxd11 Location: Chr2:74509902-74517360 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd11^{tm2.1(Hoxd11)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The floxed neo cassette was excised from Hoxd11^{tm2(Hoxd11)Mrc} via in vivo cre mediated recombination. The second copy of the Hoxd11 coding region and surrounding sequence inserted upstream of the endogenous Hoxd11 coding region was left intact. In situ hybridization indicated overexpression of Hoxd11 transcript. (J:78766)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd11 Mutation: 14 strains or lines available

References

• Original: J:78766 Boulet AM, et al., Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. Dev Biol. 2002 Sep 1;249(1):96-107
• All: 1 reference(s)