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Bmd13C57BL/6J
QTL Variant Detail
Summary
QTL variant: Bmd13C57BL/6J
Name: bone mineral density 13; C57BL/6J
MGI ID: MGI:2389169
QTL: Bmd13  Location: Chr13:56629249-56629397 bp  Genetic Position: Chr13, cM position of peak correlated region/allele: 21.73 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Bmd13 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd13 mapped to 35 cM on mouse Chromosome 13 with a peak LOD=7.73 at D13Mit13 in linkage to femoral BMD. C3H/HeJ-derived alleles confer an additively-inherited increase in BMD at Bmd13.

References
Original:  J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory