Bmd13^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Bmd13^C3H/HeJ
• Name: bone mineral density 13; C3H/HeJ
• MGI ID: MGI:2389170
• QTL: Bmd13 Location: Chr13:56629249-56629397 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 21.73 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased BMD compared to C57BL/6J. This allele confers decreased responsiveness to mechanical loading in males compared to C57BL/6J. (J:78754, J:123678)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bmd13 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd13 mapped to 35 cM on mouse Chromosome 13 with a peak LOD=7.73 at D13Mit13 in linkage to femoral BMD. C3H/HeJ-derived alleles confer an additively-inherited increase in BMD at Bmd13.

References

• Original: J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
• All: 3 reference(s)