Bmd16^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Bmd16^C3H/HeJ
• Name: bone mineral density 16; C3H/HeJ
• MGI ID: MGI:2389179
• QTL: Bmd16 Location: Chr18:46667914-46668060 bp Genetic Position: Chr18, cM position of peak correlated region/allele: 19.41 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased femoral and vertebral BMD and increased body weight compared to C57BL/6J. (J:78754)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Notes

Bmd16 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd16 mapped to 24 cM on mouse Chromosome 18 with a peak LOD=13.67 at D18Mit36 in linkage to femoral and vertebral BMD. C3H/HeJ-derived alleles confer an additively-inherited increase in femoral and vertebral BMD at Bmd16.

References

• Original: J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
• All: 3 reference(s)