Ppp1r9b^tm1Jfe
Targeted Allele Detail

Summary

• Symbol: Ppp1r9b^tm1Jfe
• Name: protein phosphatase 1, regulatory subunit 9B; targeted mutation 1, Jian Feng
• MGI ID: MGI:2389199
• Synonyms: neurabin II^-, Sp-, spinophilin-, spinophilin 1, Spl-, Spn-
• Gene: Ppp1r9b Location: Chr11:94882038-94897724 bp, + strand Genetic Position: Chr11, 59.01 cM
• Alliance: Ppp1r9b^tm1Jfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77284
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.2 kb genomic fragment containing exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of brain homogenates indicated an absence of protein in homozygous mutant mice. (J:77284)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r9b Mutation: 37 strains or lines available

References

• Original: J:77284 Feng J, et al., Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9287-92
• All: 19 reference(s)