Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:74499The Col4a3tm1Jhm mutation (the mouse model of Alport syndrome) was crossed onto a 129X1/SvJ background and a C57BL/6J background for 6 and 7 generations, respectively. This resulted in mutant lines composed of >98% 129X1/SvJ and >99% C57BL/6J background genetic material. The rate of end-stage renal failure (ESRF) progressed much more quickly in mutant animals on a 129X1/SvJ background (2 months) compared to mutant animals on a C57BL/6J background (> 6 months). Loci responsible for this difference in renal failure progression were mapped in a F1 x C57BL/6J backcross using markers spaced approximately 20 cM apart. Renf1 mapped to mouse Chromosome 9 at approximately 43 cM with a LOD score of 3.26 between D9Mit4 and D9Mit12, and Renf2 mapped to mouse Chromosome 16 at approximately 57 cM with a LOD score of 3.1 at D16Mit153. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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