Bace1^tm1Pcw
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Pcw
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Philip C Wong
• MGI ID: MGI:2389228
• Synonyms: Bace1^-, BACE1^-
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Pcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79847
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant embryos. (J:79847)

Disease models

Expression

In Mice Carrying this Mutation:

6 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:79847 Cai H, et al., BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci. 2001 Mar;4(3):233-4
• All: 65 reference(s)