Hopx^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Hopx^tm1Eno
• Name: HOP homeobox; targeted mutation 1, Eric N Olson
• MGI ID: MGI:2389233
• Synonyms: HOP^-
• Gene: Hopx Location: Chr5:77234835-77262968 bp, - strand Genetic Position: Chr5, 41.45 cM
• Alliance: Hopx^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79152
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a cassette containing a nuclear-localized lacZ and neo. Transcript was undetected by Northern blot and RT-PCR analyses of heart and liver tissues from homozygous mutant mice. Western blot analysis confirmed the absence of normal protein in heart and brain tissues. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. (J:79152)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hopx Mutation: 11 strains or lines available

References

• Original: J:79152 Shin CH, et al., Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell. 2002 Sep 20;110(6):725-35
• All: 4 reference(s)