Mwq4^DU6i
QTL Variant Detail

Summary

• QTL variant: Mwq4^DU6i
• Name: molecular weight of quadriceps QTL 4; DU6i
• MGI ID: MGI:2389240
• QTL: Mwq4 Location: unknown Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: DU6i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased muscle weight compared to DBA/2J. (J:66233)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mwq4 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTL were provided by the authors and may not be equivalent to the closest microsatellites.

Body weight QTL 9, abdominal fat percent QTL 10, molecular weight of quadriceps QTL 4, spleen weight QTL 2, abdominal fat weight QTL 10 were mapped to mouse chromosome 12 to cM positions 17, 18, 20, 21 and 21 respectively.

01.07.2015 - Curators Note: We had originally associated the body weight QTL 9 identified here, mapping to 17cM on Chr12 as Bw9. Bw9 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578, in 1998. We consider the current mapping study a separate mapping experimentand have named the QTL identified here as Bw38.

04.28.2015 - Curators Note: We had orginally associated the spleen weight QTL 2 identified here, mapping to 21 cM , as Swq2. Swq2 was orignially mapped using a different cross, an outbred cross of DU6 x DUK,in J:49578, in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Swq8.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)