Summary |
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Variant origin |
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Variant description |
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Notes |
Trait Annotation
Candidate Genes
A search for candidate genes was performed using DU6 and DU6i high body weight selection lines and lean unselected lines DUKs and DBA/2. RNA from epididymal fat tissue of 20 males from each line (DU6, DU6i, DUKs and DBA2/J) was pooled for analysis in Affymetrix GeneChips and resulted in the identification of 77 differentially expressed candidate genes. Of these, 14 genes are located in QTLs intervals affecting body weight and abdominal fat weight. Mapping and Phenotype information for this QTL, its variants and associated markersJ:66233QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTL were provided by the authors and may not be equivalent to the closest microsatellites. Body weight QTL 9, abdominal fat percent QTL 10, molecular weight of quadriceps QTL 4, spleen weight QTL 2, abdominal fat weight QTL 10 were mapped to mouse chromosome 12 to cM positions 17, 18, 20, 21 and 21 respectively.01.07.2015 - Curators Note: We had originally associated the body weight QTL 9 identified here, mapping to 17cM on Chr12 as Bw9. Bw9 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578, in 1998. We consider the current mapping study a separate mapping experimentand have named the QTL identified here as Bw38.04.28.2015 - Curators Note: We had orginally associated the spleen weight QTL 2 identified here, mapping to 21 cM , as Swq2. Swq2 was orignially mapped using a different cross, an outbred cross of DU6 x DUK,in J:49578, in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Swq8. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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