Hopx^tm1.1Joe
Targeted Allele Detail

Summary

• Symbol: Hopx^tm1.1Joe
• Name: HOP homeobox; targeted mutation 1.1, Jonathan A Epstein
• MGI ID: MGI:2389244
• Synonyms: Hop^-, Hopx^LacZ
• Gene: Hopx Location: Chr5:77234835-77262968 bp, - strand Genetic Position: Chr5, 41.45 cM
• Alliance: Hopx^tm1.1Joe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79153
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In vivo cre mediated excision of a floxed neo gene left the lacZ gene in place of the endogenous coding region. Transcript was undetected by Northern blot analysis of heart tissue isolated from newborn homozygous mutant mice. Western blot analysis showed a lack of protein in heart extracts from homozygous mutant embryos. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. (J:79153)

Expression

In Mice Carrying this Mutation:	57 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hopx Mutation: 11 strains or lines available

References

• Original: J:79153 Chen F, et al., Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development. Cell. 2002 Sep 20;110(6):713
• All: 14 reference(s)