Cacnb3^tm1Acv
Targeted Allele Detail

Summary

• Symbol: Cacnb3^tm1Acv
• Name: calcium channel, voltage-dependent, beta 3 subunit; targeted mutation 1, Adolfo Cavalie
• MGI ID: MGI:2389248
• Synonyms: Beta3-
• Gene: Cacnb3 Location: Chr15:98528721-98542410 bp, + strand Genetic Position: Chr15, 54.64 cM
• Alliance: Cacnb3^tm1Acv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79744
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 3 and all of exon 4 were replaced with a neomycin selection cassette inserted by homologous recombination. Northern and Western blot analyses of homozygous mutant mice indicated an absence of transcript and protein. (J:79744)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacnb3 Mutation: 26 strains or lines available

References

• Original: J:79744 Murakami M, et al., Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem. 2002 Oct 25;277(43):40342-51
• All: 13 reference(s)