Bhr4^DBA/2
QTL Variant Detail

Summary

• QTL variant: Bhr4^DBA/2
• Name: bronchial hyperresponsiveness 4; DBA/2
• MGI ID: MGI:2389256
• QTL: Bhr4 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:67848

Twenty-four BXD (B=C57BL/6, D=DBA/2) recombinant inbred (RI) strains were evaluated for bronchial airway hyperrsponsiveness at 4 candidate loci syntenic to human chromosome 5q31-q33, a region associated with asthma in humans. Parental strain C57BL/6 is hyporesponsive whereas parental strain DBA/2 is hyperresponsive. One candidate locus on mouse chromosome 13, Bhr4, showed significant linkage to bronchial airway hyperrsponsiveness at D13Ncvs44 (P=0.0226) and maps near possible candidate genes Il9 and Caml. Examination of Il9 revealed differences in protein and mRNA levels between parental strains C57BL/6 and DBA/2. C57BL/6 exhibits decreased Il9 expression compared to DBA/2. The authors propose Il9 may be a gene responsible for asthma in mice and humans.

References

• Original: J:67848 Nicolaides NC, et al., Interleukin 9: a candidate gene for asthma. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13175-80
• All: 1 reference(s)