Cia10^C57BL/10
QTL Variant Detail

Summary

• QTL variant: Cia10^C57BL/10
• Name: collagen induced arthritis QTL 10; C57BL/10
• MGI ID: MGI:2389260
• QTL: Cia10 Location: unknown Genetic Position: Chr13, cM position of peak correlated region/allele: 53.81 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/10

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers arthritis susceptibility compared to RIIIS/J. (J:50472)
• Inheritance: Recessive

Notes

Homozygosity for C57BL/10-derived alleles at Cia10 and Cia5 results in severe arthritis.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50472

173 (B10.RIII x RIIIS/J)F2 intercross animals were used to map novel loci associated with collagen-induced arthritis. Both strains share the H-2r MHC locus. B10.RIII is extremely susceptible to collagen-induced arthritis with 80-100% of the animals developing severe arthritis approximately 35 days after induction of disease. RIIIS/J is resistant and does not develop arthritis after induction. 55% of (B10.RIII x RIIIS/J)F1 animals develop arthritis after induction, and 45% of (B10.RIII x RIIIS/J)F2 animals develop arthritis after induction with wide variability in degree of disease severity. There appears to be a dominant, sex-influenced mode of disease inheritance. Male animals are more susceptible to arthritis than female animals. 121 markers covering 78% of the mouse genome at an average spacing of 20 cM were typed for QTL analysis.

Cia5 mapped to a region of chromosome 3 spanning 35.2 cM - 52.5 cM with a peak LOD score of 4.12 at D3Mit72 (39.7 cM). This locus was confirmed in an intercross using (B10.RIII x RIIIS/J)F2 x B10.RIII N4 backcross (N4I2) animals. B10.RIII-derived alleles contribute to recessively inherited disease susceptibility at this locus. Cia5 maps near loci for susceptibility to Theiler's murine encephalomyelitis virus (Tmevd2 at 46cM) and insulin dependent diabetes (Idd17 at 39 cM; Idd10 at 48. 5cM).

A suggestive QTL, Cia10, mapped to a region of chromosome 13 spanning 51 cM - 72 cM with a peak LOD score of 3.13 approximately 4 cM distal to D13Mit72 (51 cM). B10.RIII-derived alleles also contribute to recessively inherited disease susceptibility at this locus. Animals homozygous for B10.RIII alleles at Cia10 and Cia5 develop the most severe disease phenotype.

References

• Original: J:50472 Jirholt J, et al., Genetic linkage analysis of collagen-induced arthritis in the mouse. Eur J Immunol. 1998 Oct;28(10):3321-8
• All: 1 reference(s)