Eae13^SJL/J
QTL Variant Detail

Summary

• QTL variant: Eae13^SJL/J
• Name: experimental allergic encephalomyelitis susceptibility 13; SJL/J
• MGI ID: MGI:2389273
• QTL: Eae13 Location: Chr13:67318411-67318559 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 34.54 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased EAE susceptibility compared to B10.S/DvTe. (J:53193)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53193

Analysis of 633 (SJL/J x B10.S/DvTe)F2 mice with induced experimental allergic encephalomyelitis (EAE) indicated the presence of a quantitative locus (QTL) involved with the monophasic remitting/nonrelapsing (M-RNR) form of the disorder. Eae13, showed maximum linkage to D13Mit66 at approximately 37 cM on mouse Chromosome 13. Stratification of the data by sex indicated that the effect of Eae13 was greater in males that in females. Susceptibility is associated with the SJL allele.

References

• Original: J:53193 Butterfield RJ, et al., Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J Immunol. 1999 Mar 1;162(5):3096-102
• All: 1 reference(s)