Hpi1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hpi1^C57BL/6J
• Name: hapatic PMN infiltration 1; C57BL/6J
• MGI ID: MGI:2389297
• QTL: Hpi1 Location: Chr13:4414025-53101640 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 7.73 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased neutrophil infiltration compared to A/J. (J:69153)
• Inheritance: Not Specified

Notes

Hpi1 is epistatic to Hpi2. Animals homozygous for C57BL/6J-derived alleles at both Hpi1 and Hpi2 exhibit the highest levels of PMN infiltration.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69153

A genome wide scan was performed to map QTLs involved in hepatic PMN infiltration and necrosis in response to intraperitoneal (i.p.) LPS injection. Strain distribution patterns in AXB and BXA Recombinant Inbred strains were suggestive in mapping Hpi1 to mouse Chromosome 13. 122 (A/J X C57BL/6J)F2 total intercross animals were assayed. Hpi1 mapped to chromosome 13 (spanning 15 cM from D13Mit236 and D13Mit248) and was association with D13Mit17. Six additional markers were typed in this region giving a peak LRS (likelihood ratio statistic)score of 22.1 with marker D13Mit188. Reciprocal crosses showed Hpi1 was neither sex-linked nor imprinted. C57BL/6J animals show higher level of hepatic PMN infiltration than A/J, while F1 animals express a phenotype similar to C57BL/6J. Hpi1 appears to be epistatic to another locus, Hpi2 on Chromosome 5. Hpi2 further elevates PMN infiltration levels only in animals with the B/B genotype at Hpi1. Animals with the highest levels of PMN infiltrations had B/B genotype at both Hpi1 and Hpi2.

References

• Original: J:69153 Matesic LE, et al., Quantitative trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation. FASEB J. 2000 Nov;14(14):2247-54
• All: 1 reference(s)