Ntsr1^tm1Fer
Targeted Allele Detail

Summary

• Symbol: Ntsr1^tm1Fer
• Name: neurotensin receptor 1; targeted mutation 1, Pascual Ferrara
• MGI ID: MGI:2389321
• Synonyms: NT-1R^-
• Gene: Ntsr1 Location: Chr2:180141769-180186772 bp, + strand Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
• Alliance: Ntsr1^tm1Fer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a cassette containing GFP and neo. The deleted region encoded the amino terminal region through the second external loop. Radiohistological analysis of coronal brain sections obtained from homozygous mutant mice showed only residual binding that was putatively attributed to Ntsr2. (J:79712)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntsr1 Mutation: 31 strains or lines available

References

• Original: J:79712 Remaury A, et al., Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res. 2002 Oct 25;953(1-2):63
• All: 2 reference(s)