Pain1^A/J
QTL Variant Detail

Summary

• QTL variant: Pain1^A/J
• Name: pain 1; A/J
• MGI ID: MGI:2389397
• QTL: Pain1 Location: Chr15:75320846-90813185 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 30.11 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70963

395 markers were screened in 23 A/J x C57BL/6J (AXB) and C57BL/6J x A/J (BXA) recombinant inbred (RI) strains to identify loci associated with autonomy. Autonomy is defined as the abnormal behavior of an anesthetic limb including licking, scratching and self-injury. Denervation of the hind limb was accomplished by surgery of the sciatic and saphenous nerves. Animals were evaluated beginning 7 days after surgery. Parental strain A/J displays a high level of autonomy compared to parental strain C57BL/6J. A QTL significantly linked to autonomy, Pain1, mapped from approximately 39 cM - 44 cM on mouse Chromosome 15 with peak linkage at D15Mit28 (P=0.00002) at 43.7 cM. Pain1 maps close to Emo2, a QTL assiciated with fear, anxiety, and depression at 43.3 cM. Potential candidate genes for Pain1 include Pvalb, Bzrp, Galr3, Il2rb, Cacng2, Kcnj4, and Jrk.

J:164901

The authors show that Pain1 maps to the

interval between SNPs rs32198729 and rs3717268 (75.27?90.7 Mb

on chromosome 15. Further analysis using bioinformatics and whole-genome microarray expression analysis indicated Cacng2 as a likely candidate for the Pain1 QTL.

References

• Original: J:70963 Seltzer Z, et al., Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain. 2001 Aug;93(2):101-6
• All: 2 reference(s)