Bbaa14^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Bbaa14^C3H/HeJ
• Name: B.burgdorferi-associated arthritis 14; C3H/HeJ
• MGI ID: MGI:2389400
• QTL: Bbaa14 Location: Chr15:31927587-31927756 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

In the (C3H/HeJ X BALB/cAnN)F1 X BALB/cAnN backcross a novel QTL, Bbaa14 linked to ankle swelling mapped to Chr 15 at 17.8 cm with marker D15Mit111, LRT=15.1 accounting for 11.9% of trait variance. [Table 2.]

In the (C57BL/6N X C3H/HeJ)F1 X C57BL/6J backcross another Chr 15 QTL, linked to specific IgG, was also identified as Bbaa14. Since the two mapping populations differ curators named this QTL Bbaa31. Bbaa31 mapped from 15.6-18.8 cM between markers D15Mit24 and D15Mit154, LRT=18.3 accounting for 12.3% of variance. [Table 2.]

In the reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross a novel QTL, Bbaa22, linked to histopathology mapped to 46.9 cM with marker D15Mit24, LRT=19.8 accounting for 17.3% of variance. [Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)