Tg(ARR2/Pbsn-FGF8)3Prb
Transgene Detail

Summary

• Symbol: Tg(ARR2/Pbsn-FGF8)3Prb
• Name: transgene insertion 3, Pradip Roy-Burman
• MGI ID: MGI:2389409
• Transgene: Tg(ARR2/Pbsn-FGF8)3Prb Location: unknown
• Alliance: Tg(ARR2/Pbsn-FGF8)3Prb page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ARR2/Pbsn-FGF8)3Prb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF8 (2253)

  Fgf8	(MGI:99604)

• Mutation details: A cDNA corresponding to an alternate form of human FGF8 (FGF8b) was ligated to an enhanced rat probasin promoter and followed by an SV40 polyadenylation signal. In addition to being detected in the anterior, dorsolateral, and ventral regions of the prostate, transgenic transcript was detected in the ductus defrens, seminal vesicle, and epididymus. (J:78918)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:78918 Song Z, et al., Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res. 2002 Sep 1;62(17):5096-105
• All: 3 reference(s)